Concomitant medication polypharmacy, interactions and imperfect adherence are common in Australian adults on

Krista J Siefried1, Limin Mao, Lucette A Cysique

  • 1aSt Vincent's Centre for Applied Medical Research, St Vincent's Hospital, SydneybCentre for Social Research in HealthcNeuroscience Research Australia, University of New South Wales, SydneydNational Association of People with HIV Australia, NewtowneSchool of Public Health and Community Medicine, University of New South Wales, Sydney, New South WalesfDepartment of Infectious Diseases, Alfred Hospital and Monash UniversitygDepartment of Infectious Diseases, The Royal Women's HospitalhMonash Infectious Diseases, Monash Health, Melbourne, VictoriaiAlbion Centre, South Eastern Sydney Local Hospital Network, Sydney, New South WalesjCentre for Population Health, Burnet InstitutekMelbourne Sexual Health Centre, Alfred HealthlCentral Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VictoriamWestern Sydney Sexual Health Centre, University of Sydney, ParramattanWestmead Clinical School, Sydney Medical School, University of Sydney, Westmead, New South WalesoCentre Clinic, St Kilda, Melbourne, VictoriapHoldsworth House Medical PracticeqThe Kirby Institute, University of New South Wales, Sydney, New South Wales, AustraliarDepartment of Interdisciplinary Social Science, Utrecht University, Utrecht, The Netherlands.

AIDS (London, England)
|November 15, 2017
PubMed
Abstract

Related Concept Videos

Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
315
Pharmacokinetics: Drug–Drug Interactions01:25

Pharmacokinetics: Drug–Drug Interactions

Drug interactions occur when the pharmacological effect of one drug is altered by another substance, either enhancing or diminishing its activity. The drug whose activity is altered is known as the object drug, and the substance causing the alteration is called the agent drug or the precipitant. The net effects of these interactions are mostly undesirable, leading to decreased effectiveness or increased adverse effects. In rare cases, interactions can be beneficial, such as the enhanced...
497
Pharmacokinetics: Drug–Food and Drug–Viral Interactions01:26

Pharmacokinetics: Drug–Food and Drug–Viral Interactions

A drug interaction occurs when the concurrent use of another drug, food, or an external substance alters the pharmacological activity of a drug. This interaction can modify the action of the original drug, affecting its effectiveness and safety.Drug–food interactions are significant as they impact drug absorption, metabolism, and excretion. For example, grapefruit juice is a well-known disruptor of drug metabolism. It inhibits the cytochrome P450 3A4 enzyme, crucial for the metabolism of...
281
Drug Toxicity: Risk factors01:24

Drug Toxicity: Risk factors

Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...
27
Therapeutic Drug Monitoring: Affecting Factors01:29

Therapeutic Drug Monitoring: Affecting Factors

Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
258
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
289