Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Children Show Stronger Learning-Dependent Explicit Knowledge Than Adults After Offline Wake or Sleep Intervals.

Journal of sleep research·2026
Same author

Cognitive impairment in heart transplantation: prevalence, trajectories, and prognostic impact - a systematic review.

Aging clinical and experimental research·2026
Same author

Utility of a machine-guided tool for assessing risk behaviour associated with contracting HIV in three sites in South Africa.

Informatics in medicine unlocked·2023
Same author

Interactions between the aging brain and motor task complexity across the lifespan: balancing brain activity resource demand and supply.

Cerebral cortex (New York, N.Y. : 1991)·2023
Same author

Network-specific differences in transient brain activity at rest are associated with age-related reductions in motor performance.

NeuroImage·2022
Same author

Representational similarity scores of digits in the sensorimotor cortex are associated with behavioral performance.

Cerebral cortex (New York, N.Y. : 1991)·2022

Related Experiment Video

Updated: Feb 18, 2026

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
09:01

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

Published on: May 7, 2014

10.6K

Age-Related Declines in Motor Performance are Associated With Decreased Segregation of Large-Scale Resting State

B R King1, P van Ruitenbeek1,2, I Leunissen1

  • 1KU Leuven, Movement Control and Neuroplasticity Research Group, Department of Movement Sciences, Biomedical Sciences, Leuven, Belgium.

Cerebral Cortex (New York, N.Y. : 1991)
|November 15, 2017
PubMed
Summary

As people age, brain networks become less segregated, leading to poorer motor skills. This study links increased connectivity between brain networks to age-related motor declines.

More Related Videos

A Fine Motor Task to Study Joint Kinematics in a Preclinical Model of Neurodegenerative Disease
05:39

A Fine Motor Task to Study Joint Kinematics in a Preclinical Model of Neurodegenerative Disease

Published on: June 13, 2025

944
Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke
06:37

Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke

Published on: July 14, 2023

1.4K

Related Experiment Videos

Last Updated: Feb 18, 2026

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
09:01

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

Published on: May 7, 2014

10.6K
A Fine Motor Task to Study Joint Kinematics in a Preclinical Model of Neurodegenerative Disease
05:39

A Fine Motor Task to Study Joint Kinematics in a Preclinical Model of Neurodegenerative Disease

Published on: June 13, 2025

944
Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke
06:37

Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke

Published on: July 14, 2023

1.4K

Area of Science:

  • Neuroscience
  • Gerontology
  • Cognitive Science

Background:

  • Aging is linked to motor function decline and altered brain network organization.
  • Prior studies focused on motor networks, leaving whole-brain functional organization changes under-explored.
  • Decreased brain network segregation (increased internetwork connectivity) is a hallmark of aging.

Purpose of the Study:

  • To investigate the association between adult lifespan motor performance decline and age-related functional connectivity changes.
  • To examine connectivity within and between resting-state brain networks.
  • To understand if whole-brain network changes, not just motor network changes, relate to motor performance in aging.

Main Methods:

  • Examined functional connectivity within and between resting-state networks across the adult lifespan (ages 20-75).
  • Assessed the relationship between age-related connectivity patterns and motor performance.
  • Compared the strength of association between internetwork and intranetwork connectivity with motor performance.

Main Results:

  • Increased internetwork connectivity correlated with age was significantly associated with worse motor performance.
  • Internetwork connectivity showed a stronger association with motor performance than intranetwork connectivity.
  • These findings held true even when considering connectivity within motor-related networks.

Conclusions:

  • Age-related motor performance decline may stem from a broader breakdown in large-scale brain network organization.
  • Increased internetwork connectivity, reflecting reduced brain network segregation, is a key factor in age-related motor impairments.
  • The findings highlight the importance of whole-brain network dynamics in understanding motor aging.