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Updated: Feb 18, 2026

An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance
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The Proton-activated Receptor GPR4 Modulates Intestinal Inflammation

Yu Wang1,2, Cheryl de Vallière1, Pedro H Imenez Silva2

  • 1Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.

Journal of Crohn'S & Colitis
|November 15, 2017
PubMed
Summary

Absence of GPR4 ameliorates colitis in animal models of inflammatory bowel disease [IBD]. This suggests GPR4 plays a key role in mucosal inflammation and could be a therapeutic target for IBD treatment.

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