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Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
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Does CSF1R Blockade Turn into Friendly Fire?
1Gastrointestinal Malignancy Section, Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Cancer Cell
|November 15, 2017
Abstract:
In this issue of Cancer Cell, Kumar et al. describe how CSF1R blockade induces not only an expected deprivation of tumor-associated macrophages, but also an accumulation of tumor-infiltrating polymorphonuclear mononuclear cells caused by Cxcl-1 released from cancer-associated fibroblasts.
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