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Molecular Landscape of Non-Muscle Invasive Bladder Cancer
Joshua J Meeks1, Seth P Lerner2
1Department of Urology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.
Cancer Cell
|November 15, 2017
Abstract:
In this issue of Cancer Cell, Hurst et al. report an integrated analysis of non-invasive (stage Ta) bladder cancer. Two genomic subtypes are distinguished by chromosome 9q loss, resulting in increased AKT/PI3K/mTOR signaling. Tumors from female patients have a higher frequency of KDM6A mutations.
