Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

1.9K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
1.9K
The Thyroid Gland01:23

The Thyroid Gland

7.9K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
7.9K
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

8.1K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
8.1K
Papillary Dermis01:11

Papillary Dermis

6.1K
Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
6.1K
The Parathyroid Glands00:59

The Parathyroid Glands

5.4K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
5.4K
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

5.8K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
5.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Genome‑wide methylation profiling differentiates benign from aggressive and metastatic pituitary neuroendocrine tumors.

Acta neuropathologica·2025
Same author

[Endocrinology, diabetology and metabolism in the 150 years of the DMW - A long and sustainable relationship].

Deutsche medizinische Wochenschrift (1946)·2024
Same author

Genome-wide methylation profiling differentiates benign from aggressive and metastatic pituitary neuroendocrine tumors.

Acta neuropathologica·2024
Same author

Interobserver Agreement in Ultrasound Risk Stratification Systems for Thyroid Nodules on Static Images Versus Cine-Loop Video Sequences.

Diagnostics (Basel, Switzerland)·2024
Same author

Radiological Assessment of Different Retroperitoneal Lymph Node Measurements in Stage 1 Testicular Cancer Patients: Impact on Clinical Stage and Treatment.

Journal of clinical medicine·2024
Same author

Comparison of automated kidney stone size measurement and volumetry in photon counting CT compared to 3rd generation dual energy CT and physically measurements - an ex vivo study.

World journal of urology·2024
Same journal

Determinants of Infant Participation and Non-Participation in Primary Prevention Trials.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2026
Same journal

Inflammatory Profile of Lipedema: A Comparative Evaluation with Obese and Normal-weight Women.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2026
Same journal

Comparative Effects of Experimental Diabetes Mellitus and Glucocorticoid-Induced Hypercortisolemia on Pancreatic and Adrenal Endocrine Architecture: A Pathological Study in Rats.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2026
Same journal

Psychiatric Symptoms in Women with Mild Autonomous Cortisol Secretion Versus Non-Functioning Adrenal Adenomas: A Cross-Sectional Study.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2026
Same journal

Antisemitism as a Chronic Cardiometabolic, Endocrine, and Glutamatergic Stressor Requiring Psychometric Monitoring.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2026
Same journal

Severe Acute Respiratory Syndrome Coronavirus-2 Infection and New Changes in Thyroid Function Parameters during Hospitalization and Follow-up.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2026
See all related articles

Related Experiment Video

Updated: Feb 18, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

2.6K

Papillary Thyroid Cancer and Coexisting Autoimmune Thyroiditis.

Franziska Veit1, Dieter Graf2,3, Saskia Momberger2

  • 1Nuclear Medicine Center von Essen, Koblenz, Germany.

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|November 15, 2017
PubMed
Summary
This summary is machine-generated.

Autoimmune thyroiditis (AIT) is frequently associated with papillary thyroid cancer (PTC), particularly in younger patients, unlike follicular thyroid cancer (FTC). High TPOAb levels and lymphocytic infiltration are key indicators in PTC diagnosis.

More Related Videos

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma
04:01

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Published on: September 15, 2023

1.6K
An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
07:01

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

Published on: April 17, 2013

21.7K

Related Experiment Videos

Last Updated: Feb 18, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

2.6K
Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma
04:01

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Published on: September 15, 2023

1.6K
An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
07:01

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

Published on: April 17, 2013

21.7K

Area of Science:

  • Endocrinology and Oncology
  • Pathology and Immunology

Background:

  • Histological findings suggest a link between papillary thyroid carcinomas (PTC) and autoimmune thyroiditis (AIT).
  • Differences in histological presentation distinguish PTC from follicular thyroid carcinomas (FTC).
  • Understanding the association of AIT with differentiated thyroid cancers is crucial for diagnosis and treatment.

Purpose of the Study:

  • To evaluate the association of AIT in patients with PTC and FTC.
  • To compare the incidence of AIT markers in PTC and FTC patients against control groups.
  • To determine the correlation between thyroid autoimmunity markers and differentiated thyroid cancers.

Main Methods:

  • Retrospective analysis of 100 thyroidectomies with confirmed differentiated thyroid carcinomas (67 PTC, 33 FTC).
  • Inclusion of two control groups: 60 patients with benign nodular goiter (no surgery) and 100 patients with benign nodular goiter (surgery).
  • Assessment of anti-thyroid peroxidase antibodies (TPOAbs) and histological lymphocytic infiltration (LI).

Main Results:

  • High TPOAbs found in 35% of PTC patients; LI detected in 48% of PTC.
  • Chronic autoimmune thyroiditis (AIT/fAIT) present in 25% of PTC, with 94% showing high TPOAb.
  • FTC patients showed significantly lower TPOAb levels (12%) compared to PTC.

Conclusions:

  • Different degrees of LI and high TPOAb levels are significantly increased in PTC, especially in younger individuals.
  • A strong correlation exists between LI and high TPOAb levels in PTC.
  • Thyroid autoimmunity signs may aid in surgical decisions for indeterminate thyroid nodules when focal autonomy is excluded.