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Updated: Feb 18, 2026
Murine Kidney Transplant Technique
Published on: October 20, 2015
Study of Bacterial Infections Among Patients Receiving Kidney Transplant in Mashhad, Iran
Davood Mansury1, Azad Khaledi, Kiarash Ghazvini
1>From the Antimicrobial Resistance Research Center, Kashan University of Medical Sciences and Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
Objectives:
Over the past 2 decades, significant advances have been made in the management of infections after transplant; however, transplant recipients are still at high risk of infectious complications. This study aimed to evaluate the prevalence of bacterial infections and antimicrobial resistance patterns in kidney transplant recipients.
Materials And Methods:
This cross-sectional study included 356 patients who received kidney transplants, regardless of the underlying disease, from 2013 to 2015 at the Montaserieh Transplant Hospital (Mashhad, Iran). Clinical samples collected from patients were sent to the microbiology laboratory for culture processing. Typing of bacteria was conducted, and susceptibility testing was performed according to the Clinical and Laboratory Standards Institute guideline by use the of disk diffusion agar method. Data were then analyzed by SPSS software (SPSS: An IBM Company, IBM Corporation, Armonk, NY, USA) using chi-square test.
Results:
Among 356 kidney recipients (206 men and 150 women), 115 (32.3%) received transplants from living donors and 241 (67.7%) received transplants from deceased donors. Of 356 total patients, 112 patients (31.5%) had an infection at various times after transplant. The most common gram-negative and gram-positive isolated bacteria were Escherichia coli and coagulase-negative Staphylococcus, with prevalence rates of 66.1% and 48.6%. Most of the isolates were resistant against selected antibiotics.
Conclusions:
Because of the high prevalence of infection among transplant patients, infection prevention should receive more attention, and antibiotic susceptibility should be determined before treatment.
Insights
A study found over 31% of kidney transplant recipients experienced bacterial infections, with Escherichia coli and coagulase-negative Staphylococcus being most common. High antimicrobial resistance necessitates improved infection prevention and susceptibility testing.
Area of Science:
- Nephrology
- Infectious Diseases
- Microbiology
Background:
- Kidney transplant recipients face significant risks of infectious complications despite advances in management.
- Bacterial infections remain a major concern, impacting patient outcomes post-transplantation.
Purpose of the Study:
- To determine the prevalence of bacterial infections in kidney transplant recipients.
- To analyze antimicrobial resistance patterns of common bacterial isolates in this patient population.
Main Methods:
- A cross-sectional study involving 356 kidney transplant recipients from 2013-2015.
- Bacterial culture, typing, and antibiotic susceptibility testing using the disk diffusion method.
- Statistical analysis of clinical and microbiological data.
Main Results:
- A prevalence of 31.5% for bacterial infections was observed among the studied kidney transplant recipients.
- Escherichia coli (66.1%) and coagulase-negative Staphylococcus (48.6%) were the most frequently isolated bacteria.
- A high degree of resistance to tested antibiotics was noted among the bacterial isolates.
Conclusions:
- The high infection rate underscores the need for enhanced infection prevention strategies in kidney transplant recipients.
- Empirical antibiotic treatment should be guided by local antimicrobial susceptibility data.
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