The association between serum 25-hydroxyvitamin D3 concentration and serum lipids in the rural population of China
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Updated: Feb 18, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
Huina Ge1, Hualei Sun1, Teng Wang1
1Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Henan, 450001, China.
Background:
Vitamin D deficiency is implicated in some diseases, including cardiovascular. Few studies have assessed the correlation between 25-hydroxyvitamin D3 [25(OH) D3] and serum lipids. In this study, we explored the correlation between serum 25(OH) D3 concentrations and serum lipids with a typical sample of the rural population in China.
Methods:
Face-to-face research was used to gather some basic information. Fasting serum concentrations of 25-(OH) D3, total cholesterol (TC), triglyceride (TG), HDL cholesterol (HDL-C) and, LDL cholesterol (LDL-C) tested in the laboratory.
Results:
The mean of serum 25(OH) D3 level was 28.71 ± 29.29 ng/mL. The results showed that the dyslipidemia was strongly associated with gender (P = 0.031), drinking (P = 0.043), high-fat diet intake (P = 0.017), HDL-C (P<0), TG (P<0), body mass index (BMI) (P<0) and serum 25(OH)D3 levels (P = 0.002). There was a positive correlation between serum 25(OH)D3 and HDL-C (P<0) in all groups. The relationship between 25(OH) D3 and LDL-C (P = 0.024) was discovered only in normal lipid group. The multivariable adjusted odds ratio (95%CI) of hypoalphalipoproteinemia/HDL and dyslipidemia by comparing the sufficiency vs. the deficiency serum 25-(OH) D3 level were 0.31 (0.192, 0.499) (P = 0.001) and 0.52 (0.36, 0.73) (P = 0.005), respectively.
Conclusions:
Serum 25(OH) D3 concentrations were associated with the serum lipids level and the association was different in normal serum lipid group and dyslipidemia group. With the increase of serum 25(OH) D3 levels, the incidence of dyslipidemia decreased.
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