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Can integrating the Memory Support Intervention into cognitive therapy improve depression outcome? Study protocol for
Allison G Harvey1, Lu Dong2, Jason Y Lee2
1Department of Psychology, University of California, Berkeley, 3210 Tolman Hall #1650, Berkeley, CA, 94720-1650, USA. aharvey@berkeley.edu.
Trials
|November 16, 2017
Summary
This study tests a Memory Support Intervention to improve outcomes for major depressive disorder (MDD) patients receiving cognitive therapy (CT). Enhanced memory support may lead to better treatment adherence and results.
Area of Science:
- Clinical Psychology
- Psychiatry
- Mental Health Interventions
Background:
- Patient memory for treatment is often poor, impacting adherence and outcomes.
- Memory support strategies can mitigate the effects of memory impairment.
- The Memory Support Intervention aims to improve patient recall and treatment effectiveness.
Purpose of the Study:
- To conduct a confirmatory efficacy trial of the Memory Support Intervention for major depressive disorder (MDD).
- To test if the Memory Support Intervention improves illness course and functional outcomes compared to standard care.
- To investigate the role of patient memory in mediating treatment outcomes.
Main Methods:
- 178 adults with MDD will be randomized to Cognitive Therapy (CT) + Memory Support or CT-as-usual.
- Assessments at baseline, post-treatment, and 6/12-month follow-ups.
- Mediation and moderation analyses will explore treatment mechanisms and subgroup effects.
Main Results:
- (Study protocol - results pending)
Conclusions:
- The Memory Support Intervention is designed to be broadly applicable across disorders and treatments.
- This trial focuses on MDD and CT as a foundational step.
- Future research may extend the intervention to other conditions and settings.
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