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Pseudotumor cerebri induced by danazol.

L M Hamed1, J S Glaser, N J Schatz

  • 1Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, FL 33101.

American Journal of Ophthalmology
|February 15, 1989
PubMed
Summary
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Danazol therapy can cause intracranial hypertension with papilledema, a condition that resolves after discontinuing the drug. This suggests a potential drug-induced complication requiring careful patient monitoring and alternative treatment options.

Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Danazol is a medication used to treat conditions such as cyclic neutropenia and immune hemolytic anemia.
  • Intracranial hypertension is a condition characterized by elevated pressure within the skull.

Observation:

  • Two patients on danazol developed intracranial hypertension with papilledema.
  • One patient had no identifiable cause, while the other showed cerebral venous sinus thrombosis.
  • Papilledema resolved in both cases after discontinuing danazol.

Findings:

  • Seven additional cases of pseudotumor cerebri linked to danazol were reported.
  • All reported cases of drug-induced papilledema resolved after danazol cessation.
  • The findings suggest a causal relationship between danazol and intracranial hypertension.

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Implications:

  • Clinicians should consider danazol as a potential cause of intracranial hypertension and papilledema.
  • Alternative therapies should be explored in patients developing these symptoms during danazol treatment.
  • Increased awareness and monitoring are crucial for patients undergoing danazol therapy.