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Related Experiment Video

Updated: Feb 18, 2026

Visualization and Quantification of TGFβ/BMP/SMAD Signaling under Different Fluid Shear Stress Conditions using Proximity-Ligation-Assay

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Thrombospondin-4 in tissue remodeling.

Olga Stenina-Adognravi¹, Edward F Plow¹

¹Department of Molecular Cardiology, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA.

Matrix Biology : Journal of the International Society for Matrix Biology

|November 16, 2017

Summary

Thrombospondin-4 (TSP-4) is an extracellular matrix protein with unique roles in promoting blood vessel growth and reducing fibrosis. This review highlights TSP-4

Keywords:

Angiogenesis Extracellular matrix (ECM)Fibrosis Myocardium Nociception Skeletal muscle

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Last Updated: Feb 18, 2026

Visualization and Quantification of TGFβ/BMP/SMAD Signaling under Different Fluid Shear Stress Conditions using Proximity-Ligation-Assay

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Published on: October 27, 2020

Area of Science:

Biochemistry
Cell Biology
Extracellular Matrix Biology

Background:

Thrombospondin-4 (TSP-4) is a member of the thrombospondin protein family.
Recent studies reveal novel functions of TSP-4 in various physiological systems.

Purpose of the Study:

To review the properties and functions of TSP-4.
To discuss the role of TSP-4 in tissue remodeling.

Main Methods:

Literature review of existing studies on TSP-4.
Comparative analysis of TSP-4 functions with other thrombospondins.

Main Results:

TSP-4 uniquely promotes angiogenesis, unlike other thrombospondins.
TSP-4 reduces fibrosis and collagen production, contrasting with TSP-1 and TSP-2.
TSP-4 exhibits structural functions within the extracellular matrix.

Conclusions:

TSP-4 is a significant regulator of extracellular matrix organization and production.
TSP-4 plays a crucial role in tissue remodeling during embryonic development and in response to injury.