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Updated: Feb 18, 2026

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
Published on: March 7, 2025
The Next Frontier: Head and Neck Cancer Immunoprevention
J Silvio Gutkind1, Jack D Bui2
1Department of Pharmacology, Moores Cancer Center, University of California, San Diego, California. sgutkind@ucsd.edu jbui@ucsd.edu.
Abstract:
Restoring T cell-mediated antitumor immunity by targeting immune checkpoint inhibitors in head and neck squamous cell carcinoma (HNSCC) results in immunomodulation and durable remissions. However, the overall response rate to these immunotherapies in HNSCC is only approximately 20%. This raises the possibility that immunologic intervention earlier in the HNSCC continuum, such as in oral premalignant lesions (OPL) could elicit an increased therapeutic response. New experimental studies suggest that immune therapies can be used for HNSCC prevention rather than therapy. Given the current excitement for precision medicine, these findings support the future development of multimodality approaches for preventive immune oncology. Cancer Prev Res; 10(12); 681-3. ©2017 AACRSee related article by Jin Wang, et al., p. 684.
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