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Simvastatin Ameliorates Diabetic Cardiomyopathy by Attenuating Oxidative Stress and Inflammation in Rats

Nawal M Al-Rasheed1,2, Nouf M Al-Rasheed1, Iman H Hasan1

  • 1Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

Oxidative Medicine and Cellular Longevity
|November 16, 2017
PubMed

Insights

Simvastatin treatment improved body weight and reduced hyperglycemia in diabetic rats with cardiomyopathy. The study found simvastatin alleviates diabetic cardiomyopathy by reducing oxidative stress, inflammation, and apoptosis.

Area of Science:

  • Cardiology
  • Endocrinology
  • Pharmacology

Background:

  • Diabetic cardiomyopathy (DCM) is a cardiac complication of diabetes.
  • Hyperglycemia-induced oxidative stress and inflammation contribute to DCM pathogenesis.

Purpose of the Study:

  • To investigate the protective effects of simvastatin on experimental diabetic cardiomyopathy.
  • To elucidate the mechanisms underlying simvastatin's action in DCM.

Main Methods:

  • Diabetes was induced in rats using streptozotocin.
  • Rats received simvastatin treatment for 90 days.
  • Cardiac function, oxidative stress markers, inflammatory mediators, and apoptosis were assessed.

Main Results:

  • Simvastatin improved body weight, attenuated hyperglycemia, and reduced cardiac hypertrophy in diabetic rats.
  • Simvastatin decreased cardiac injury markers (CK-MB, troponin I), lipid peroxidation, and inflammation (NF-κB).
  • Simvastatin reversed decreased antioxidant defenses and reduced cardiac caspase-3 activity.

Conclusions:

  • Simvastatin effectively alleviates experimental diabetic cardiomyopathy.
  • The cardioprotective effects are attributed to the attenuation of oxidative stress, inflammation, and apoptosis.

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