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Related Experiment Videos

Falls in peripheral eosinophil counts parallel the late asthmatic response.

W O Cookson1, C F Craddock, M K Benson

  • 1Osler Chest Unit, Churchill Hospital, Headington, Oxford, United Kingdom.

The American Review of Respiratory Disease
|February 1, 1989
PubMed
Summary

Peripheral eosinophil counts decrease 9 hours after allergen challenge in asthma patients. This eosinophil drop correlates with late asthmatic responses and increased bronchial hyperresponsiveness.

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Area of Science:

  • Immunology
  • Pulmonology
  • Allergy

Background:

  • Asthma is characterized by airway inflammation and hyperresponsiveness.
  • Eosinophils play a key role in allergic inflammation and asthma pathogenesis.
  • The kinetics of peripheral eosinophils following allergen exposure in asthma are not fully understood.

Purpose of the Study:

  • To investigate the changes in peripheral eosinophil counts after allergen inhalation in asthmatic subjects.
  • To correlate these eosinophil count changes with the late asthmatic response and bronchial hyperresponsiveness.

Main Methods:

  • 14 asthmatic subjects underwent allergen and control inhalation challenges.
  • Peripheral eosinophil counts were measured at various time points before and after challenges.

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  • Bronchial responsiveness to histamine was assessed at 3 and 24 hours post-allergen challenge.

    • Main Results:

    • A significant fall in peripheral eosinophil counts was observed 9 hours after allergen challenge, unlike the control day.
    • This decrease in eosinophils correlated strongly with the magnitude of the late asthmatic response.
    • The eosinophil count reduction also correlated with increased bronchial responsiveness to histamine at 3 and 24 hours.

    Conclusions:

    • Eosinophil kinetics following allergen challenge are linked to the development of late-phase asthmatic reactions.
    • Changes in peripheral eosinophil counts reflect the severity of late asthmatic responses and worsening bronchial hyperreactivity.