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Updated: Feb 18, 2026

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution
Published on: August 16, 2016
Biomimetic Peptide-Gated Nanoporous Membrane for On-Demand Molecule Transport
Kai Xiao1,2, Kai Wu3, Lu Chen1
1Key Laboratory of Bio-inspired Materials and Interfacial Science, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
Abstract:
The controllable molecule transport is crucial to realize many highly valuable applications both in vivo and in vitro. Nanoporous membranes, with nanoscopic pores, high porosity, uniform pore dimensions, and controllable surface chemical properties, hold tremendous potential to achieve this function. Herein, we report a nano-gating system for on-demand molecule transport based on a peptide-gated nanoporous membrane. Acting as gatekeeper, the peptides introduced to the nanoporous membrane provide an opportunity to realize on-demand on-off states via reversible conformational switching of the peptides. This nano-gating system offers sustained release and can be used as a sophisticated molecule transport platform for localized drug delivery with a feedback function.
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