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Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue
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Advanced Management of Severe Keloids.
Thomas Hagele1, Hoka Nyanda2, Nishit Patel2
1Department of Dermatology and Cutaneous Surgery, University of South Florida, Morsani College of Medicine; Tampa, FL; thomashagele@gmail.com.
Skinmed
|November 16, 2017
Summary
Effective keloid treatment is challenging. Intralesional steroids are first-line, while newer options like interferon and radiation show promise, but some therapies should be avoided.
Area of Science:
- Dermatology
- Wound Healing
- Medical Therapeutics
Background:
- Keloids significantly impair patient health and quality of life.
- Current keloid treatments often yield suboptimal clinical responses.
- Numerous therapeutic strategies exist for managing keloid scars.
Purpose of the Study:
- To review currently available therapeutic options for keloid management.
- To identify effective and ineffective treatments for keloid scars.
- To guide clinicians in selecting optimal keloid treatment strategies.
Main Methods:
- Systematic review of existing literature on keloid therapeutics.
- Analysis of clinical efficacy and outcomes for various treatment modalities.
- Evaluation of emerging therapies and established treatments.
Main Results:
- Intralesional steroid injection is the primary first-line treatment.
- Imiquimod, interferon, and 5-fluorouracil offer alternatives to excessive steroid use.
- Radiation and laser therapies demonstrate emerging efficacy; pressure dressings, vitamin E, ablative laser, and surgical excision are associated with poor outcomes.
Conclusions:
- Several therapeutic options can improve keloid management outcomes.
- Emerging therapies like radiation and laser therapy show promise.
- Certain treatments, including surgical excision, should be avoided due to unsatisfactory results. Further research is warranted.
