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Updated: Feb 18, 2026

High-Resolution Comparison of Bacterial Conjugation Frequencies
Published on: January 10, 2019
Comparative genomics of type 1 IncC plasmids from China
Lizhi Ma1, Zhe Yin2, Defu Zhang2,3
1Department of Emergency Medicine, General Hospital of Chinese People's Armed Police Forces, Beijing 100039, China.
Aim:
This study dealt with genomic characterization of type 1 IncC resistance plasmids, capable of spreading across taxonomic borders, from China.
Materials & Methods:
p112298-tetA was sequenced and compared with type 1 IncC reference plasmid pR148 and two available sequenced type 1 IncC plasmids pHS36-NDM and pVAS3-1 from China.
Results:
These plasmids contained one or more exogenous resistance islands, which included the ARI-A islands, the ARI-B islands, the ISEcp1-blaCMY units and the bla KPC-2 region and were inserted at various sites in the IncC backbone and thus represented three distinct lineages.
Conclusion:
Complex rearrangement and homologous recombination events have occurred during evolution of p112298-tetA, making it significantly differ modularly from the other three plasmids with respect to both plasmid backbone and exogenous resistance regions.
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