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Smad3-STAT3 crosstalk in pathophysiological contexts.

Yuka Itoh1, Masao Saitoh1, Keiji Miyazawa1

  • 1Department of Biochemistry, Graduate School of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409-3898, Japan.

Acta Biochimica Et Biophysica Sinica
|November 16, 2017
PubMed
Summary

Smad3 and STAT3 signaling pathways interact, cooperating or opposing each other in cellular processes like tumorigenesis and T cell differentiation. This review explores their complex crosstalk in various biological contexts.

Keywords:
STATSmadTGF-βcrosstalk

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Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Immunology

Background:

  • Smad3 and STAT3 are key intracellular signaling molecules.
  • Smad3 transmits signals from TGF-β superfamily members.
  • STAT3 transmits signals from cytokines via gp130/JAK kinases.

Purpose of the Study:

  • To review the crosstalk between Smad3 and STAT3.
  • To highlight context-dependent interactions.
  • To discuss implications in various biological processes.

Main Methods:

  • Literature review of Smad3 and STAT3 signaling.
  • Analysis of crosstalk mechanisms.
  • Synthesis of findings across different biological contexts.

Main Results:

  • Smad3 and STAT3 signaling pathways exhibit context-dependent crosstalk.
  • Interactions can be cooperative or antagonistic.
  • Crosstalk influences tumorigenesis, EMT, fibrosis, and T cell differentiation.

Conclusions:

  • The interplay between Smad3 and STAT3 is crucial for cellular functions.
  • Understanding this crosstalk is vital for therapeutic strategies.
  • Further research is needed to elucidate specific mechanisms.