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Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
Published on: December 8, 2014
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Faecal transplantation for IBD management-pitfalls and promises
M N Quraishi1, T Critchlow1, N Bhala1
1Department of Gastroenterology, Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Birmingham B15 2TH, UK.
British Medical Bulletin
|November 16, 2017
Summary
Faecal microbiota transplantation (FMT) shows early promise for ulcerative colitis (UC) treatment. However, research continues into FMT
Area of Science:
- Gastroenterology and Microbiology
- Investigational Therapies
Background:
- Inflammatory bowel disease (IBD) research is exploring novel treatments.
- Faecal microbiota transplantation (FMT) efficacy in Clostridium difficile colitis suggests potential for IBD.
Purpose of the Study:
- To review current evidence on FMT for inflammatory bowel disease (IBD).
- To assess the efficacy and controversies surrounding FMT in IBD treatment.
Main Methods:
- Review of case series and randomized controlled trials (RCTs) on FMT in IBD since 1989.
- Focus on ulcerative colitis (UC) with three published RCTs.
Main Results:
- Promising short to medium-term efficacy signals for FMT in UC.
- Ongoing controversies regarding FMT methodology, mechanisms, and safety in IBD.
Conclusions:
- Numerous FMT trials for IBD in adults and children are actively recruiting.
- Future research will likely focus on Crohn's disease, pouch surgery, and advanced microbiome analysis (virome, mycobiome).
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