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Cornusides A-O, Bioactive Iridoid Glucoside Dimers from the Fruit of Cornus officinalis
Xian-Sheng Ye1,2, Jun He3, Yung-Chi Cheng4
1School of Life Sciences & School of Chinese Medicine Sciences, Beijing University of Chinese Medicine , Beijing 100029, People's Republic of China.
Abstract:
Fifteen new and rare iridoid glucoside dimers, cornusides A-O (1-15), and 10 known iridoid glucosides (16-25) were isolated from the fruit of Cornus officinalis. These new chemical structures were established through spectroscopic analysis (UV, IR, HRESIMS, 1D and 2D NMR). Compounds 1-25 were tested for their inhibitory activities by measuring IL-6-induced STAT3 promoter activity in HepG2 cells, and 3, 12, 17, 22, and 23 showed inhibitory effects, with IC50 values of 11.9, 12.2, 14.0, 7.0, and 6.9 μM, respectively.
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