Association between urinary manganese and blood pressure: Results from National Health and Nutrition Examination Survey (NHANES), 2011-2014

Cynthia Wu ^1,2, Jessica G Woo ¹, Nanhua Zhang ¹

⁰Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States of America.

Plos One +

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November 16, 2017

View abstract on PubMed

Summary

Higher urinary manganese levels were linked to lower blood pressure in adults. This suggests manganese may help protect against hypertension and cardiovascular disease.

Area Of Science

Environmental Health
Nutritional Science
Cardiovascular Health

Background

Manganese is an essential trace mineral vital for numerous physiological processes.
Dietary intake and occupational exposure are primary sources of manganese.
Hypertension is a significant risk factor for cardiovascular disease.

Purpose Of The Study

To investigate the association between urinary manganese levels and blood pressure.
To explore the potential role of manganese in hypertension prevention.

Main Methods

Utilized data from the National Health and Nutrition Examination Survey (NHANES) 2011-2014 cycles.
Employed linear regression analyses to examine relationships between urinary manganese and blood pressure metrics (systolic and diastolic).
Adjusted for key covariates including age, sex, BMI, race/ethnicity, and antihypertensive medication use.

Main Results

A statistically significant negative association (p<0.01) was observed between urinary manganese and both systolic and diastolic blood pressure.
This association remained significant after controlling for potential confounding factors.

Conclusions

Urinary manganese levels may be inversely associated with blood pressure.
Manganese exposure could play a protective role against hypertension.
Further research is warranted to elucidate the mechanisms underlying manganese's effect on blood pressure and cardiovascular health.