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Updated: Sep 26, 2025

Neuroimaging-Guided TMS–EEG for Real-Time Cortical Network Mapping

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Published on: June 13, 2025

Relationship between rTMS effects and MEP features before rTMS.

Kazuhisa Nojima¹, Keiji Iramina²

¹Graduate School of Systems Life Sciences, Kyushu University, 1-1-3 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

Neuroscience Letters

|November 16, 2017

Summary

This summary is machine-generated.

Repetitive transcranial magnetic stimulation (rTMS) can modulate cortical excitability. This study found that baseline motor evoked potential (MEP) amplitude and latency influence how 1 Hz rTMS affects the motor cortex.

Keywords:

Cortical excitability Motor evoked potentials Repetitive transcranial magnetic stimulation

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Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation

Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation

Published on: February 23, 2020

Area of Science:

Neuroscience
Neuromodulation
Clinical Neurophysiology

Background:

Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technique.
rTMS can modulate cortical excitability, with inhibitory effects typically observed at frequencies below 1 Hz.
1 Hz rTMS may induce facilitative effects, but this is dependent on stimulation parameters and individual subject characteristics.

Purpose of the Study:

To investigate subject-specific features influencing the effect of 1 Hz rTMS.
To determine how baseline motor evoked potential (MEP) characteristics correlate with rTMS-induced modulation.
To identify predictors of rTMS response based on pre-stimulation MEPs.

Main Methods:

Measurement of motor evoked potentials (MEPs) under varying rTMS conditions (intensity, pulse number).
Analysis of MEP features (amplitude, latency) prior to rTMS application.
Correlation analysis between pre-rTMS MEP features and observed rTMS effects.

Main Results:

Baseline MEP amplitude and onset latency significantly influence the rTMS effect.
Negative correlations were observed between MEP amplitude/latency and rTMS modulation.
MEPs with smaller amplitude and earlier latency were less affected by 1 Hz rTMS inhibition.

Conclusions:

Subject-specific MEP features, particularly amplitude and latency, are crucial determinants of 1 Hz rTMS outcomes.
Understanding these pre-stimulation MEP characteristics can help predict individual responses to rTMS.
This research provides insights into optimizing rTMS protocols by considering individual neurophysiological profiles.