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Updated: Feb 18, 2026

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Curcumin: A Natural Pan-HDAC Inhibitor in Cancer

Sara Saffar Soflaei1,2, Amir Abbas Momtazi-Borojeni2,3, Muhammed Majeed4

  • 1Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Current Pharmaceutical Design
|November 17, 2017
PubMed
Abstract

Insights

Curcumin, a turmeric extract, shows potential as an anti-cancer agent by inhibiting histone deacetylases (HDACs). Further clinical studies are needed to confirm its efficacy in cancer patients.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pharmacology

Background:

  • Histone deacetylases (HDACs) are crucial in disease pathogenesis, particularly cancer.
  • HDAC inhibitors are FDA-approved for cancer treatment, driving research for new agents.
  • Curcumin, a natural polyphenol from turmeric, exhibits anticancer properties and targets various molecules.

Purpose of the Study:

  • To investigate the modulatory effects of curcumin on HDACs in various cancer types.
  • To explore curcumin's potential as an HDAC inhibitor for cancer therapy.

Main Methods:

  • Systematic literature search for studies on curcumin's effect on HDACs.
  • Analysis of in vitro and in vivo data from identified articles.

Main Results:

  • Curcumin inhibits HDAC activity and down-regulates expression of HDAC types 1, 2, 3, 4, 5, 6, 8, and 11 in cancer models.
  • Curcumin's modulation of HDACs is a potential mechanism for its anti-cancer effects.
  • HDAC2 expression is upregulated by curcumin in non-cancer models (COPD, heart failure).

Conclusions:

  • In vitro and in vivo data support curcumin's HDAC inhibitory activity.
  • Clinical evidence for curcumin's efficacy as an adjunct cancer treatment is currently lacking.
Keywords:
Curcumincancerchemotherapyepigenetichistone deacetylasetumor.

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