Ellagic Acid: A Logical Lead for Drug Development?
Related Experiment Video
Updated: Feb 18, 2026

Lethality Bioassay Using Artemia salina L.
Published on: October 11, 2022
Abolfazl Shakeri1, Mohammad Reza Zirak2, Amirhossein Sahebkar3,4
1Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Background:
Naturally occurring polyphenols are the subject of increasing attention due to their potent antioxidant activity and their marked effects on the prevention of various oxidative stress-associated diseases such as cancer. Ellagic acid (EA) is an herbal polyphenol that is structurally a condensed dimer of gallic acid.
Methods:
This review aims to provide a comprehensive and updated overview on the biological activities of EA and potential therapeutic applications.
Results:
EA is found in fruits and nuts, either in the combined form with hexahydroxydiphenic acid or in the bound form (ellagitannins). EA exhibits many biological properties such as antioxidant, anti-diabetic, anticancer and apoptosis-inducing activities. These biological and pharmacological properties are relevant to the treatment of several human diseases.
Conclusion:
Owing to its multiple mechanisms of action, EA represents a potential therapeutic agent against human diseases particularly cancer.
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