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Related Concept Videos

Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Hematopoiesis01:21

Hematopoiesis

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The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
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Overview of Hematopoiesis01:20

Overview of Hematopoiesis

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Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Lineage Commitment01:21

Lineage Commitment

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Commitment is the  process whereby stem cells:
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Isolation Method for Long-Term and Short-Term Hematopoietic Stem Cells
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Aging of hematopoietic stem cells.

Gerald de Haan1, Seka Simone Lazare1

  • 1European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Blood
|November 17, 2017
PubMed
Summary

Aging hematopoietic stem cells (HSCs) lose self-renewal capacity, increasing disease risk. This review explores molecular mechanisms of HSC aging, focusing on reversible, cell-intrinsic pathways for potential clinical interventions.

Area of Science:

  • Hematology
  • Stem Cell Biology
  • Aging Research

Background:

  • Hematopoietic stem cells (HSCs) are crucial for lifelong blood cell production.
  • HSCs decline in function with age, losing self-renewal and regenerative potential.
  • Aging is linked to increased cellular dysfunction and hematological pathologies.

Purpose of the Study:

  • To review the molecular mechanisms underlying hematopoietic stem cell aging.
  • To discuss the cell-intrinsic factors contributing to HSC aging.
  • To explore the potential reversibility of HSC aging processes and clinical relevance.

Main Methods:

  • Review of current scientific literature on HSC aging.
  • Analysis of molecular pathways involved in stem cell senescence.

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  • Discussion of age-associated changes in HSC function.

    • Main Results:

    • HSC aging is primarily driven by cell-intrinsic molecular pathways.
    • Age-related decline in HSC self-renewal and regenerative capacity is observed.
    • Certain aspects of HSC aging may be amenable to therapeutic intervention.

    Conclusions:

    • Understanding HSC aging mechanisms is key to addressing age-related hematological diseases.
    • Targeting cell-intrinsic pathways could offer novel therapeutic strategies.
    • Interventions in HSC aging hold significant clinical potential for improving healthspan.