Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

5.2K
Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
5.2K
Morphogenesis02:19

Morphogenesis

30.6K
Plant morphogenesis—the development of a plant’s form and structure—involves several overlapping developmental processes, including growth and cell differentiation. Precursor cells differentiate into specific cell types, which are organized into the tissues and organ systems that make up the functional plant.
30.6K
Cell Size01:22

Cell Size

132.8K
Cell sizes vary widely among and within organisms. Bacterial cells range between 1-10 micrometers (μm)and are considerably smaller than most eukaryotic cells. The smallest bacteria are 0.1 μm in diameter—about a thousand times smaller than eukaryotic cells, which typically range from 10-100 μm.
Surface Area
Cells can take in nutrients and water via diffusion through the plasma membrane itself or through specific channels in the membrane. The area of the membrane surrounding...
132.8K
The Cell Cycle Control System01:28

The Cell Cycle Control System

5.9K
The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
5.9K
Enlargement of the Plasma Membrane01:22

Enlargement of the Plasma Membrane

2.5K
Cell division and enlargement are processes that require precise control. The control ensures that cell division cannot proceed unless the cell has grown to a specific size. A spherical, dividing cell requires an approximately 1.6X increase in its surface area to double its volume. The secretory pathway also has a significant role in cell membrane enlargement. Secretory vesicles that bud off from the Golgi apparatus and later fuse with the plasma membrane during exocytosis are a major source of...
2.5K
Molecular Factors Affecting Cell Division01:27

Molecular Factors Affecting Cell Division

4.0K
Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A natural programmable metamaterial controls 3D curvature of compound eyes.

Nature communications·2026
Same author

Advancing mechanobiology from single molecules to complex cellular systems.

Nature nanotechnology·2026
Same author

Expanding the fly eye gene regulatory network: From Drosophila to the hoverfly Episyrphus balteatus.

PLoS genetics·2026
Same author

A Semimechanistic Ocular Pharmacokinetic Model for ADVM-022 Gene Therapy Describing the Dose-Exposure Relationship in Monkeys and the Scaling to Human.

Molecular pharmaceutics·2025
Same author

Gill regeneration in the mayfly <i>Cloeon</i> uncovers new molecular pathways in insect regeneration.

Open biology·2024
Same author

Intrathecal administration of Anti-Nogo-A antibody in macaque monkeys: Pharmacokinetics, tissue penetration and target interaction.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics·2024
Same journal

Domain innovation and deeply conserved intrinsic disorders in eukaryotic argonaute.

Open biology·2026
Same journal

Deep learning in tumour genomics: from multi-omics integration to precision oncology.

Open biology·2026
Same journal

Understanding GnRH: local systems, signalling mechanisms and implications in female health.

Open biology·2026
Same journal

The evolution and functional significance of neuropeptide cocktails: insights from SALMFamides in asteroid echinoderms.

Open biology·2026
Same journal

Structural basis of Drosophila insulin receptor activation by DILP2 hormone.

Open biology·2026
Same journal

Parental rearing shapes brain functional networks and socio-sexual behaviours in the prairie vole.

Open biology·2026
See all related articles

Related Experiment Video

Updated: Feb 18, 2026

Real Time and Repeated Measurement of Skeletal Muscle Growth in Individual Live Zebrafish Subjected to Altered Electrical Activity
11:41

Real Time and Repeated Measurement of Skeletal Muscle Growth in Individual Live Zebrafish Subjected to Altered Electrical Activity

Published on: June 16, 2022

2.5K

Growth and size control during development.

Jannik Vollmer1,2, Fernando Casares3, Dagmar Iber4,2

  • 1D-BSSE, ETH Zürich, Mattenstrasse 26, 4058 Basel, Switzerland.

Open Biology
|November 17, 2017
PubMed
Summary
This summary is machine-generated.

Organ size is genetically determined yet influenced by environment, following species-specific allometry rules. This review explores growth termination mechanisms in Drosophila, focusing on how organs achieve their precise size.

Keywords:
Drosophilagrowth controlgrowth terminationmathematical models

More Related Videos

Surgical Size Reduction of Zebrafish for the Study of Embryonic Pattern Scaling
06:31

Surgical Size Reduction of Zebrafish for the Study of Embryonic Pattern Scaling

Published on: May 3, 2019

7.3K
A Cell-Free Assay Using Xenopus laevis Embryo Extracts to Study Mechanisms of Nuclear Size Regulation
14:27

A Cell-Free Assay Using Xenopus laevis Embryo Extracts to Study Mechanisms of Nuclear Size Regulation

Published on: August 8, 2016

8.8K

Related Experiment Videos

Last Updated: Feb 18, 2026

Real Time and Repeated Measurement of Skeletal Muscle Growth in Individual Live Zebrafish Subjected to Altered Electrical Activity
11:41

Real Time and Repeated Measurement of Skeletal Muscle Growth in Individual Live Zebrafish Subjected to Altered Electrical Activity

Published on: June 16, 2022

2.5K
Surgical Size Reduction of Zebrafish for the Study of Embryonic Pattern Scaling
06:31

Surgical Size Reduction of Zebrafish for the Study of Embryonic Pattern Scaling

Published on: May 3, 2019

7.3K
A Cell-Free Assay Using Xenopus laevis Embryo Extracts to Study Mechanisms of Nuclear Size Regulation
14:27

A Cell-Free Assay Using Xenopus laevis Embryo Extracts to Study Mechanisms of Nuclear Size Regulation

Published on: August 8, 2016

8.8K

Area of Science:

  • Developmental Biology
  • Genetics
  • Evolutionary Biology

Background:

  • Organ size and shape are species-specific, adhering to allometric principles.
  • Environmental factors like nutrition can alter organism size, but organ proportions remain consistent within a species.
  • Growth termination determines the final organ size, a process not fully understood.

Purpose of the Study:

  • To investigate the mechanisms underlying organ growth termination.
  • To understand how related species evolve different organ sizes.
  • To review current research, primarily using Drosophila melanogaster, on growth cessation.

Main Methods:

  • Focus on studies conducted in Drosophila melanogaster as a model organism.
  • Analysis of allometry and its role in organ size determination.
  • Review of literature on growth regulation and termination.

Main Results:

  • Organ growth rate declines with developmental time, a universal biological observation.
  • Growth termination is linked to robustness, plasticity, and environmental influences on target size.
  • Drosophila serves as a key model for dissecting growth control mechanisms.

Conclusions:

  • Understanding organ growth termination is crucial for explaining species-specific organ sizes and developmental plasticity.
  • Further research in Drosophila can elucidate fundamental principles of growth control applicable across the animal kingdom.
  • The interplay between genetic programming and environmental factors shapes final organ size.