Related Experiment Video
Updated: Feb 18, 2026
03:46
Author Spotlight: Coproparasitoscopic Examination of Dog Stools for Control and Prevention of Zoonotic Parasite Diseases
Published on: December 15, 2023
4.3K
Accidental afloqualone intoxication in two dogs.
Jin-Ok Ahn1, Won-Joung Jaung1, Sang-Heum Won1
1Department of Veterinary Internal Medicine and Institute of Veterinary Science, College of Veterinary Medicine, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.
The Journal of Veterinary Medical Science
|November 17, 2017
Summary
Accidental afloqualone ingestion caused severe toxic effects in two dogs, including seizures and respiratory depression. Supportive care led to recovery, marking the first reported canine afloqualone intoxication case.
Area of Science:
- Veterinary Toxicology
- Canine Pharmacology
Background:
- Afloqualone is a human muscle relaxant for back pain.
- Accidental drug ingestion in pets poses significant health risks.
Observation:
- Two dogs ingested afloqualone tablets.
- Clinical signs included vomiting, respiratory depression, seizures, ataxia, bradycardia, and hematuria.
Findings:
- Supportive treatment with fluid diuresis, furosemide, and propofol was initiated.
- Flumazenil, a GABA antagonist, was ineffective in controlling seizures.
- Both dogs recovered fully with intensive supportive care.
Implications:
- This is the first documented case of afloqualone intoxication in dogs.
- Highlights the potential toxicity of human medications in veterinary patients.
- Emphasizes the need for careful medication storage and owner education to prevent accidental poisonings.
Related Concept Videos
01:14Prevention of Further Absorption of Poison
1.3K
In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
1.3K
01:26Pharmaceutical Poisoning: Potential Scenarios
19
Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
19
01:26Anticholinesterase Agents: Poisoning and Treatment
1.7K
Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
1.7K
01:26Pharmaceutical Poisoning: Treatment Strategies
37
Treatment strategies for poisoning are a critical aspect of emergency medicine, focusing on preventing the absorption of toxins and enhancing their elimination. When a poisoning incident occurs, the first response is to halt exposure and decontaminate the patient, particularly through gastrointestinal (GI) methods if the poison was ingested.Gastrointestinal Decontamination Techniques:Activated charcoal is the cornerstone of GI decontamination. It works through adsorption, binding the toxin to...
37
01:23Toxicity Testing in Animals
25
Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
25
01:24Drug Toxicity: Risk factors
27
Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...
27