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Background data on NOD/Shi-scid IL-2Rγnull mice (NOG mice)
Kenichiro Kasahara1, Yachiyo Fukunaga1, Saori Igura1
1BoZo Research Center Inc., Tsukuba Research Institute.
The Journal of Toxicological Sciences
|November 17, 2017
Summary
This study details the health and characteristics of NOD/Shi-scid IL-2Rγnull (NOG) mice, essential for immunology research. Findings cover survival rates, clinical signs, hematology, and histology up to 52 weeks of age.
Area of Science:
- Immunology
- Animal Models
- Preclinical Research
Background:
- NOD/Shi-scid IL-2Rγnull (NOG) mice are severely immunodeficient models.
- Understanding NOG mouse background data is crucial for research applications.
Purpose of the Study:
- To establish comprehensive background data for NOG mice up to 52 weeks of age.
- To inform the appropriate use of NOG mice in various research fields.
Main Methods:
- 120 NOG mice (20/sex/group) were examined at 7, 26, and 52 weeks.
- Evaluations included survival, clinical observations, hematology, blood chemistry, and histology.
Main Results:
- High survival rate (95%) at 52 weeks.
- Observed clinical signs: circling behavior, hunchback posture.
- Hematological changes: decreased lymphocytes, increased WBCs.
- Histological findings: lymphoid hypoplasia, spongiotic changes in nerve tissue, tubular aggregates in skeletal muscle.
- Low incidences of tumors and other lesions, except uterine polyps.
Conclusions:
- NOG mice exhibit specific physiological and pathological characteristics up to 52 weeks.
- This data supports the optimized utilization of NOG mice in scientific research.
- Provides essential reference for xenograft and humanized mouse studies.
