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Related Concept Videos

Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
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Positron Emission Tomography01:29

Positron Emission Tomography

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Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
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Updated: Feb 18, 2026

Management of Respiratory Motion Artefacts in 18F-fluorodeoxyglucose Positron Emission Tomography using an Amplitude-Based Optimal Respiratory Gating Algorithm
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Abnormal Fluorodeoxyglucose Uptake in Lung without Structural Abnormality on Computed Tomography.

Prathyusha Bikkina1, Swapna Kotha2, Zakir Ali1

  • 1Department of Nuclear Medicine and PET-CT, Basavatarakam Indo American Cancer Hospital, Hyderabad, Telangana, India.

Indian Journal of Nuclear Medicine : IJNM : the Official Journal of the Society of Nuclear Medicine, India
|November 17, 2017
PubMed
Summary
This summary is machine-generated.

Fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET-CT) scans can show lung uptake due to infection, inflammation, or metastases. Rare cases of uptake without CT abnormality may mimic cancer, highlighting the importance of PET-CT interpretation.

Keywords:
False positivefluorodeoxyglucose positron emission tomography-computed tomographyiatrogenicmicrothrombus and embolism

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Area of Science:

  • Nuclear Medicine
  • Oncology
  • Radiology

Background:

  • Fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET-CT) is a vital imaging tool in cancer management.
  • Understanding normal FDG biodistribution and potential false-positive findings is crucial for accurate interpretation.
  • Pulmonary FDG uptake typically correlates with structural abnormalities on CT, indicating infection, inflammation, or metastases.

Purpose of the Study:

  • To highlight rare causes of pulmonary FDG uptake without corresponding CT abnormalities.
  • To emphasize the potential for false-positive findings in PET-CT interpretation.
  • To underscore the importance of hybrid PET-CT imaging for accurate cancer staging.

Main Methods:

  • Review of cases with pulmonary FDG uptake on PET-CT.
  • Correlation of FDG uptake patterns with CT findings.
  • Analysis of potential causes for discordant findings.

Main Results:

  • Pulmonary FDG uptake can occur without CT abnormalities in rare instances.
  • These findings may be attributed to inflammatory vascular microthrombi or iatrogenic microembolism.
  • Misinterpretation as metastases is a risk, particularly in known cancer patients.

Conclusions:

  • Awareness of rare causes of pulmonary FDG uptake is essential for avoiding misdiagnosis.
  • Hybrid PET-CT imaging is critical for differentiating true metastatic disease from benign findings.
  • Accurate interpretation relies on integrating PET and CT data to avoid false-positive results.