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Early Changes in Platelet Size and Number in Patients with Acute Coronary Syndrome

Zora Sušilović Grabovac1, Darija Baković1,2, Mislav Lozo1

  • 1Department of Cardiology, University of Split Hospital Center, Split, Croatia.

The International Journal of Angiology : Official Publication of the International College of Angiology, Inc
|November 17, 2017
PubMed

Insights

Mean platelet volume (MPV) and platelet count (PLT) show early biphasic changes in acute myocardial infarction (AMI) patients. These dynamics offer new insights into platelet behavior following AMI.

Area of Science:

  • Cardiology
  • Hematology
  • Clinical Medicine

Background:

  • Platelets (PLTs) play a crucial role in acute coronary syndrome (ACS).
  • Mean platelet volume (MPV) reflects platelet activation and function.
  • Understanding early changes in PLT and MPV is vital for ACS management.

Purpose of the Study:

  • To investigate early temporal changes in platelet count (PLT) and mean platelet volume (MPV) in different ACS manifestations.
  • To assess the predictive value of MPV within the ACS spectrum.
  • To identify novel dynamics in MPV and PLT count in acute myocardial infarction (AMI).

Main Methods:

  • Prospective study enrolling 134 ACS patients (76 completed).
  • Measurement of PLT and MPV at admission and at 1, 3, 72 hours, and 7 days.
  • Analysis of patients with unstable angina, non-ST elevation myocardial infarction, and ST-elevation myocardial infarction.

Main Results:

  • A decrease in PLT and MPV was observed in all ACS groups within 3 hours of hospital admission.
  • An increase in PLT and MPV was noted at 72 hours and 7 days, specifically in patients with AMI.
  • Biphasic changes in early MPV and PLT count dynamics were identified in AMI patients.

Conclusions:

  • Early biphasic changes in platelet count and MPV are characteristic of AMI.
  • These findings suggest a rapid platelet response in AMI, warranting further investigation into their underlying mechanisms.

Keywords:
acute coronary syndromeearly changeslarge plateletsmean platelet volumeplatelet activationplatelet countplatelet function

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