Related Experiment Videos
Ifosfamide-induced renal tubular defects
1Department of Medicine, University of Missouri-Columbia.
Cancer
|February 15, 1989
Summary
Fractionated ifosfamide (IFF) therapy, previously considered safe for kidneys, may cause unexpected nephrotoxicity. This study identified renal abnormalities and proximal tubular defects in patients receiving fractionated IFF, highlighting a unique toxicity.
Area of Science:
- Oncology
- Nephrology
- Pharmacology
Background:
- High-dose, bolus ifosfamide (IFF) therapy is associated with unexpected nephrotoxicity.
- Fractionated IFF schedules are generally considered to have a lower risk of renal injury, with only microscopic hematuria being common.
- Ifosfamide is being investigated for various cancers, including lymphomas, gynecologic malignancies, and sarcomas.
Purpose of the Study:
- To report renal abnormalities in patients receiving single-agent, fractionated ifosfamide.
- To investigate potential proximal tubular defects in patients treated with fractionated ifosfamide.
Main Methods:
- Case report describing four patients with malignant lymphoma.
- Detailed renal function studies in two patients.
Main Results:
- Four patients receiving fractionated ifosfamide exhibited renal abnormalities.
- Two patients demonstrated evidence of proximal tubular dysfunction.
Conclusions:
- Fractionated ifosfamide therapy may be associated with previously unreported nephrotoxicity.
- A proximal tubular defect is suggested as a unique toxicity of fractionated ifosfamide doses.