Enantioselective palladium(0)-catalyzed intramolecular cyclopropane functionalization: access to dihydroquinolones,
J Pedroni1, T Saget1, P A Donets1
1Laboratory of Asymmetric Catalysis and Synthesis , Institute of Chemical Sciences and Engineering , Ecole Polytechnique Fédérale de Lausanne , EPFL SB ISIC LCSA, BCH 4305 , CH-1015 Lausanne , Switzerland .
Abstract:
Taddol-based phosphoramidite ligands enable enantioselective palladium(0)-catalyzed C-H arylation of cyclopropanes. The cyclized products are obtained in high yields and enantioselectivities. The reported method provides efficient access to a broad range of synthetically attractive cyclopropyl containing dihydroquinolones and dihydroisoquinolones as well as allows for an efficient enantioselective construction of the 7-membered ring of the cyclopropyl indolobenzazepine core of BMS-791325.
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