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Related Experiment Videos

Ability of a benign tumor to decrease spontaneous food intake and body weight in rats.

Y Kawashima1, A C Campos, M M Meguid

  • 1Department of Surgery, University Hospital, SUNY Health Science Center, Syracuse 13210.

Cancer
|February 15, 1989
PubMed
Summary
This summary is machine-generated.

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Tumor size, not malignancy, may cause anorexia and weight loss. Benign tumors in rats reduced food intake by 15% and carcass weight by 15.2%, mimicking cancer cachexia. This suggests physical tumor burden contributes to these symptoms.

Area of Science:

  • Oncology
  • Pathology
  • Physiology

Background:

  • Malignant tumors often cause anorexia, reduced food intake, and weight loss.
  • The role of physical tumor size in these effects is not fully understood.

Purpose of the Study:

  • To investigate if a benign tumor mass can induce anorexia and weight loss similar to malignant tumors.
  • To determine the impact of tumor physical size on physiological changes.

Main Methods:

  • Rats were induced with a benign cystic tumor using carrageenan injection.
  • Measurements included daily food intake, body weight, tumor weight, and serum albumin levels.
  • Histological examination of tumor and tissue samples was performed.

Main Results:

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  • Carrageenan induced benign cystic tumors (average 41g by day 21).
  • Food intake decreased by ~15% and carcass weight by 15.2% in tumor-bearing rats.
  • Serum albumin decreased, liver weight reduced, and spleen weight increased in study rats.

Conclusions:

  • Benign tumor mass can induce anorexia and weight loss, mimicking cancer cachexia.
  • Physical tumor burden may significantly contribute to anorexia and weight loss, independent of malignancy.
  • These findings highlight the impact of tumor size on host physiology.