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Glomerulopathy Associated With Moderate Obesity

Yusuke Okabayashi1, Nobuo Tsuboi1, Takaya Sasaki1

  • 1Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.

Kidney International Reports
|November 17, 2017
PubMed
Abstract

Insights

Moderately obese individuals (BMI 25-30) can develop a kidney disease similar to obesity-related glomerulopathy. This condition, characterized by low glomerular density, affects patients with moderate obesity and warrants further investigation.

Area of Science:

  • Nephrology
  • Pathology
  • Endocrinology

Background:

  • Obesity-related glomerulopathy is a known kidney disease in individuals with a body mass index (BMI) of 30 kg/m² or higher.
  • However, moderate obesity (BMI < 30 kg/m²) may also be associated with similar renal pathology.

Purpose of the Study:

  • To investigate the occurrence and characteristics of glomerulopathy in patients with moderate obesity (grade 1 obesity).
  • To compare kidney disease features between patients with grade 1 obesity and those with higher grades of obesity.

Main Methods:

  • Retrospective analysis of 20 patients with grade 1 obesity (25 ≤ BMI < 30 kg/m²) and persistent proteinuria.
  • Comparison with 20 patients with grade 2 or higher obesity (BMI ≥ 30 kg/m²) and 31 healthy kidney transplant donors.

Main Results:

  • Patients with grade 1 obesity exhibited male predominance (85%) and high hypertension incidence (80%), similar to the higher obesity group.
  • Histologic findings in grade 1 obesity included low glomerular density and glomerulomegaly, characteristic of obesity-related glomerulopathy.
  • Glomerular density and volume were comparable between grade 1 and grade 2+ obesity groups, differing significantly from healthy controls.

Conclusions:

  • Glomerulopathy resembling obesity-related glomerulopathy can affect individuals with moderate obesity.
  • Factors such as low glomerular density may contribute to susceptibility to this kidney disease, independent of BMI alone.
Keywords:
body mass indexglomerular densityhyperfiltrationobesityrenal biopsy

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