Related Experiment Video
Updated: Feb 18, 2026
04:51
Author Spotlight: Functionalizing Metal-Organic Frameworks: Advancements, Challenges, and the Power of Post-Synthetic Ligand Exchange
Published on: June 23, 2023
4.3K
Covalent post-assembly modification in metallosupramolecular chemistry
Derrick A Roberts1, Ben S Pilgrim, Jonathan R Nitschke
1Department of Chemistry, University of Cambridge, Lensfield Road CB21EW, UK. jrn34@cam.ac.uk.
Chemical Society Reviews
|November 17, 2017
Summary
Covalent post-assembly modification (PAM) enhances metallosupramolecular complexes by enabling modular, late-stage functionalization. This review explores diverse PAM strategies, expanding synthetic possibilities in supramolecular chemistry.
Area of Science:
- Supramolecular Chemistry
- Organic Chemistry
- Materials Science
Background:
- Metallosupramolecular complexes are assembled structures held by metal-ligand coordination.
- Post-assembly modification (PAM) allows for late-stage functionalization of these complexes.
- Covalent PAM utilizes chemical reactions to modify pre-assembled structures.
Purpose of the Study:
- To review the diverse applications of covalent post-assembly modification (PAM) in metallosupramolecular chemistry.
- To highlight recent advancements in covalent PAM strategies.
- To provide insights into future challenges and opportunities in the field.
Main Methods:
- Review of existing literature on covalent PAM in metallosupramolecular chemistry.
- Categorization of covalent PAM strategies based on their application.
- Analysis of key examples and their significance.
Main Results:
- Covalent PAM enables modular derivatization of pre-assembled metallosupramolecular complexes.
- PAM strategies include metal-preorganized covalent synthesis, grafting functionalities, stabilizing metastable complexes, and triggering structural transformations.
- These methods significantly expand the accessible chemical space for supramolecular synthesis.
Conclusions:
- Covalent PAM is a versatile tool for tailoring metallosupramolecular architectures.
- Continued development of covalent PAM will drive innovation in supramolecular chemistry and materials science.
- Future research should focus on novel reaction development and exploring new applications.
Related Concept Videos
02:51Metal-Ligand Bonds
24.6K
The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
24.6K
01:23Properties of Organometallic Compounds
1.7K
Organometallic compounds are compounds that contain a carbon–metal bond. Carbon belongs to an organyl group like alkyl, aryl, allyl, or benzyl groups. The metal can be from Group I or Group II of the periodic table, a transition metal, or a semimetal.
1.7K
02:04Covalently Linked Protein Regulators
9.7K
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
These groups modify specific amino acids in a protein....
9.7K
02:04Covalently Linked Protein Regulators
2.1K
2.1K
02:32Bonding in Metals
53.5K
Metallic bonds are formed between two metal atoms. A simplified model to describe metallic bonding has been developed by Paul Drüde called the “Electron Sea Model”.
53.5K
02:34Structural Isomerism
21.8K
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can...
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can...
21.8K