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Updated: Feb 18, 2026

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
Published on: November 10, 2013
Synthesis, characterization, and anticancer activity of two mixed ligand copper(ii) complexes by regulating the
Xiu-Ying Qin1, Ya-Nan Wang2, Xin-Ping Yang2
1College of Pharmacy, Guilin Medical University, Guangxi Guilin, 541004, China. xyqin6688@163.com and Guangxi Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor, Guangxi Medical University, Nanning, 530021, China.
Abstract:
The single crystals of two novel mixed-ligand copper(ii)-based complexes were obtained and characterized. These complexes can remarkably induce apoptosis, inhibit proliferation, suppress migration and metastasis, and inhibit angiogenesis to inhibit the growth of cervical cancer by down-regulating the expressions of the important proteins FAK, Akt and Erk1/2 or their phosphorylated proteins p-FAK, p-Akt, and p-Erk1/2 downstream of the VEGF/VEGFR2 signaling pathway.

