Related Experiment Video
Updated: Feb 18, 2026
Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
Published on: August 13, 2019
Evaluation of Immediate Implants Augmented with Autogenous Bone/Melatonin Composite Graft in the Esthetic Zone: A
Hala H A Hazzaa1,2, Naglaa Sh El-Kilani1, Shadia Abd-Elhameed Elsayed3,4
1Department of Oral Medicine, Periodontology, Diagnosis and Oral Radiology, Faculty of Dentistry, Al-Azhar University (Girls Branch), Cairo, Egypt.
Purpose:
To evaluate the clinical and radiographic outcomes following the application of autogenous bone (ABG)/melatonin composite graft around immediate implants in the esthetic zone compared to ABG alone.
Materials And Methods:
Twenty-six patients with two nonrestorable anterior/premolar teeth were randomly classified into two equal groups. Dental implants were immediately inserted either with ABG (control group) or ABG/melatonin (test group). Outcome measures were peri-implant sulcus depth (PD), gingival index (GI), and wound healing scores. Cone beam computed tomography (CBCT) was recorded at baseline, 6, and 9 months.
Results:
At the end of the study, a significant difference was shown in the mean of marginal bone loss between the control group (1.91 mm ± 0.42) and the test group (0.84 mm ± 0.34) at p = 0.0001. The test group showed a significant gain in bone density, 500.73 ± 40.92, versus 420.14 ± 38.33 in the control group (p = 0.0001). There was a statistically significant difference between the control group (0.68 ± 0.42) versus the test group (0.45 ± 0.49; p = 0.044) in GI. PD was significantly reduced at the end of the study in the test group (0.42 mm ± 0.50; p = 0.002), with a similar significant improvement in the healing scores (p = 0.026).
Conclusion:
Within the limitations of this study, immediate implants augmented with ABG/melatonin composite graft would be a valuable option in the esthetic zone.
