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Advances in chronic cerebral circulation insufficiency.

Da Zhou1,2,3, Ran Meng1,2,3, Si-Jie Li1,2

  • 1Departments of Neurology and Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.

CNS Neuroscience & Therapeutics
|November 17, 2017
PubMed
Summary

Chronic cerebral circulation insufficiency (CCCI) is a widespread condition linked to stroke and dementia. This review covers its epidemiology, causes, and treatments for better understanding and management.

Keywords:
chronic cerebral circulation insufficiencyclinical manifestationdiagnosisexperimental researchtreatment

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Area of Science:

  • Neurology
  • Vascular Medicine
  • Gerontology

Background:

  • Chronic cerebral circulation insufficiency (CCCI) represents a persistent state of reduced blood flow to the brain, stemming from diverse underlying causes.
  • It is strongly associated with significant neurological outcomes, including ischemic stroke, vascular cognitive impairment, and vascular dementia.
  • These conditions contribute substantially to global disability and mortality.

Purpose of the Study:

  • To provide a comprehensive overview of the current understanding of CCCI.
  • To summarize recent advancements in the epidemiology, pathophysiology, and etiology of CCCI.
  • To discuss clinical manifestations, diagnostic approaches, and potential therapeutic strategies for CCCI.

Main Methods:

  • This review synthesizes existing literature on chronic cerebral circulation insufficiency.
  • It focuses on epidemiological data, experimental research findings, and established pathophysiological mechanisms.
  • Clinical, imaging, and etiological aspects are analyzed, alongside therapeutic interventions and future research directions.

Main Results:

  • CCCI is characterized by long-term cerebral blood flow reduction with multifactorial origins.
  • It is a critical precursor and contributor to ischemic stroke, cognitive decline, and dementia.
  • Current understanding encompasses its epidemiology, pathophysiology, clinical presentation, and diagnostic tools.

Conclusions:

  • CCCI is a significant clinical state, not merely an independent disease, impacting brain health globally.
  • Effective management requires understanding its diverse etiologies and associated risks like stroke and dementia.
  • Further research is needed to refine diagnostic criteria and develop targeted therapeutic regimens.