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Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Time for a new zeitgeist in perinatal mental health
Fiona Judd1,2,3, Louise Kathryn Newman1,4, Angela A Komiti1,4
11 Department of Psychiatry, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, VIC, Australia.
Insights
Focusing on high-risk caregivers, particularly those with attachment difficulties, is crucial for preventing infant developmental disorders. Early intervention can break the cycle of intergenerational mental health issues.
Area of Science:
- Perinatal Psychiatry
- Developmental Psychology
- Clinical Psychology
Background:
- Perinatal depression and anxiety have received significant research and funding for decades.
- A shift in focus towards 'high-risk' caregivers is proposed.
- High-risk caregivers are defined by potential attachment/relationship difficulties due to personal history, trauma, or mental health conditions.
Purpose of the Study:
- To advocate for increased funding and research into high-risk caregivers and their infants.
- To propose early intervention strategies for this population.
- To highlight the potential for preventing infant developmental disorders and intergenerational cycles of severe personality disorder.
Main Methods:
- This study is primarily a conceptual argument and proposal.
- It defines 'high-risk' caregivers based on specific criteria.
- It proposes an intervention focus on maternal mental health and infant interaction.
Main Results:
- The abstract does not present empirical results but argues for a change in research and funding priorities.
- It posits that early intervention can prevent infant developmental disorders.
- It suggests breaking the transgenerational cycle of severe personality disorder development.
Conclusions:
- Current focus on perinatal depression/anxiety should be rebalanced with investment in high-risk caregiver-infant dyads.
- Early, targeted interventions can mitigate risks for infant development.
- Addressing caregiver mental health and interactional patterns is key to preventing long-term negative outcomes.
Abstract:
Perinatal depression, and to a lesser extent anxiety, has been the focus of interest for perinatal psychiatrists for several decades. Policy and substantial funding has supported this. We argue that it is now time to change this focus and to invest greater funding to support clinical and research effort in 'high-risk' caregivers and their infants. We define high-risk caregivers as those who are likely to have attachment and relationship difficulties with their infant as a result of their own developmental experiences, personality difficulties and/or trauma-related mental disorders, often complicated by substance abuse, depression and anxiety. We propose that early intervention with such caregivers, focussing on both maternal mental health and on the needs of the infant for responsive and sensitive interaction and emotional care, would contribute to prevention of infant developmental disorders, with real gains to be made in breaking the transgenerational cycle of development of severe personality disorder.
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