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Updated: Feb 18, 2026

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TAZ responds to fluid shear stress to regulate the cell cycle

Hyun Jung Lee1,2, Adesuwa Ewere1,2, Miguel F Diaz1,2

  • 1a Children's Regenerative Medicine Program , Department of Pediatric Surgery , University of Texas Health Science Center at Houston , TX , USA.

Cell Cycle (Georgetown, Tex.)
|November 17, 2017
PubMed
Summary

Shear stress from lymphatic flow activates the TAZ protein in prostate cancer cells. This activation promotes cell proliferation and DNA synthesis, influencing cancer cell behavior in lymphatics.

Keywords:
Cancer cellsSignal transductionTAZTranscription factorsYAP1biomechanical forcelymphaticsmechanotransductionprostate cancershear stress

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