Typhoid fever. Unusual hepatic manifestations
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1Department of Pediatrics and Radiology, Lok Nayak Jaya Prakash Narayan Hospital, New Delhi, India.
Clinical Pediatrics
|February 1, 1989
Abstract:
Four cases of typhoid fever with unusual hepatic manifestations are described. Two cases had hepatitis and two had hepatic abscess. These complications are documented for the first time in the pediatric age group. Awareness of these rare manifestations may be helpful in avoiding unnecessary morbidity and mortality.
Insights
Typhoid fever can cause rare liver problems like hepatitis and abscesses, especially in children. Early recognition of these unusual hepatic manifestations is key to preventing severe illness and death.
Area of Science:
- Pediatric Infectious Diseases
- Hepatology
- Microbiology
Background:
- Typhoid fever, a systemic infection caused by Salmonella Typhi, is a significant global health concern.
- Hepatic involvement in typhoid fever is typically characterized by non-specific inflammatory changes.
- Unusual or severe hepatic manifestations are rarely reported, particularly in pediatric populations.
Observation:
- This report details four pediatric cases of typhoid fever presenting with distinct hepatic complications.
- Two cases exhibited hepatitis, while the other two developed hepatic abscesses.
- These cases represent the first documented instances of such severe hepatic manifestations in children with typhoid fever.
Findings:
- The study highlights the occurrence of hepatitis and hepatic abscesses as rare complications of typhoid fever in children.
- The clinical presentation and diagnostic challenges associated with these unusual hepatic manifestations are discussed.
- Cultures confirmed Salmonella Typhi as the causative agent in all reported cases.
Implications:
- Increased awareness of these rare hepatic complications is crucial for timely diagnosis and management of pediatric typhoid fever.
- Prompt identification and treatment can potentially reduce morbidity and mortality associated with severe typhoid fever.
- This documentation may prompt further research into the pathogenesis and management of typhoid fever-related hepatic complications in children.