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Related Experiment Videos

Patch testing with nickel chloride in a hydrogel.

A Fullerton1, T Menné, A Hoelgaard

  • 1Department of Pharmaceutics, Royal Danish School of Pharmacy, Copenhagen.

Contact Dermatitis
|January 1, 1989
PubMed
Summary

This study explored nickel chloride (NiCl2) hydrogels as a patch test alternative for nickel allergy. A 2% NiCl2 hydrogel showed potential to reduce false-negative results in diagnosing contact dermatitis.

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Area of Science:

  • Dermatology
  • Allergology
  • Materials Science

Background:

  • Standard patch testing for nickel allergy uses 5% nickel sulfate (NiSO4) in petrolatum.
  • Hydrogels offer a potential alternative vehicle for delivering allergens in patch testing.

Purpose of the Study:

  • To evaluate various concentrations of nickel chloride (NiCl2) in a hydrogel as an alternative to standard nickel patch test materials.
  • To assess the efficacy and safety of NiCl2 hydrogels in patients with suspected contact allergy.

Main Methods:

  • Patch test responses were recorded in 430 patients with known or suspected contact allergy.
  • Different concentrations of NiCl2 were formulated into a hydrogel and compared to 5% NiSO4 petrolatum.
  • Reactions were monitored to assess response frequency and irritancy.

Main Results:

  • NiCl2 concentrations of 1% or less in hydrogel failed to elicit responses in some patients allergic to 5% NiSO4.
  • A 2% NiCl2 hydrogel demonstrated a slight increase in response frequency, potentially reducing false-negative reactions.
  • The hydrogel formulation improved topical bioavailability of nickel ions, but also increased irritant reactions.

Conclusions:

  • A 2% NiCl2 hydrogel may serve as a useful alternative vehicle for water-soluble allergens, particularly in cases with a positive history but negative standard patch test.
  • Methocel-E-4M hydrogel shows promise for diagnosing nickel contact allergy, though irritancy needs consideration.

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