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A Microfluidic Model of Biomimetically Breathing Pulmonary Acinar Airways
Published on: May 9, 2016
An In Silico Subject-Variability Study of Upper Airway Morphological Influence on the Airflow Regime in a
Yu Feng1, Jianan Zhao2, Xiaole Chen3
1School of Chemical Engineering, Oklahoma State University, Stillwater, OK 74078, USA. yu.feng@okstate.edu.
Abstract:
Determining the impact of inter-subject variability on airflow pattern and nanoparticle deposition in the human respiratory system is necessary to generate population-representative models, useful for several biomedical engineering applications. Thus, the overall research objective is to quantitatively correlate geometric parameters and coupled transport characteristics of air, vapor, and nanoparticles. Focusing on identifying morphological parameters that significantly influence airflow field and nanoparticle transport, an experimentally validated computational fluid-particle dynamics (CFPD) model was employed to simulate airflow pattern in three human lung-airway configurations. The numerical results will be used to generate guidelines to construct a representative geometry of the human respiratory system.
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