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Functionalized Solid-State Nanopore Integrated in a Reusable Microfluidic Device for a Better Stability and

Jean Roman1, Nathalie Jarroux1, Gilles Patriarche2

  • 1LAMBE, Université Evry, CNRS, CEA, Université Paris-Saclay , Evry F-91025, France.

ACS Applied Materials & Interfaces
|November 17, 2017
PubMed
Summary

This study presents a reusable microfluidic system with a decorated membrane for enhanced single nanopore sensing. The system improves ionic conductance and device lifetime for reliable biomolecule and particle detection.

Keywords:
ionic conductancemicrofluidicsnanopore functionalizationnanopore transportpolymer brushproteinsolid-state nanopore

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Area of Science:

  • Nanotechnology
  • Biophysics
  • Microfluidics

Background:

  • Single nanopore electrical detection is valuable for biomolecule and particle analysis.
  • Control over solid-state membrane surfaces and microfluidic integration is crucial for nanopore devices.
  • Current methods face challenges in fluid exchange and device longevity.

Purpose of the Study:

  • To develop a reusable microfluidic system for improved nanopore sensing.
  • To enhance ionic conductance and operational lifetime of nanopore devices.
  • To demonstrate reliable detection of nanoparticles and proteins using the developed system.

Main Methods:

  • Fabrication of a reusable microfluidic system integrating a decorated membrane.
  • Modification of the membrane to enhance ionic conductance and device stability.
  • Integration of the system for controlled fluid exchange of analytes and buffers.
  • Electrical characterization and detection experiments.

Main Results:

  • The microfluidic system demonstrated easier analyte and buffer management.
  • Significant enhancement in nanopore ionic conductance was achieved.
  • The system showed improved nanopore device lifetime.
  • Reliable detection of gold nanorods and spherical proteins was successfully demonstrated.

Conclusions:

  • The developed reusable microfluidic system offers a robust platform for single nanopore sensing.
  • The integration of decorated membranes significantly improves device performance and longevity.
  • This approach facilitates efficient and reliable electrical detection of various analytes.