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Published on: October 29, 2017
Brain Maturation-Differences in Biochemical Composition of Fetal and Child's Brain
Andrzej Urbanik1, Monika Cichocka1, Justyna Kozub1
1a Department of Radiology , Uniwersytet Jagiellonski w Krakowie Collegium Medicum , Krakow , Poland.
Introduction:
The aim of this study was to evaluate differences in 1H MRS spectra of the brain of fetuses and children from 6 to 11 years of age.
Material And Methods:
21 healthy fetuses in the third trimester and 22 children were examined using the proton nuclear magnetic resonance. The relative metabolite concentrations to the sum of all metabolites were calculated.
Results:
In the 1H MRS spectra of the brain from fetuses and children, there are the same characteristic peaks: N-acetylaspartate (NAA), creatine (Cr), choline (Cho), and myo-inositol (mI). NAA/Σ, NAA/Cr, and Cr/Σ concentrations are significantly higher and Cho/Σ, Cho/Cr, mI/Σ, and mI/Cr are significantly lower in children than in the fetuses.
Conclusions:
It was found that the brain metabolism changes from fetal life to childhood. The results of this study may provide a valuable basis for further research on brain maturation and "healthy aging."
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