Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Enhancing spontaneous recovery after stroke: a randomized controlled trial.

Brain communications·2026

Same author

Ninety-Seven Percent of Trials Investigating Robotic Interventions in Physiotherapy Contained Abstract Spin: A Meta-Research Review.

Cochrane evidence synthesis and methods·2026

Same author

Modulation of primary motor cortex after experimentally induced and use-dependent plasticity in young and older adults.

Experimental brain research·2025

Same author

A novel TMS framework for assessing neurophysiological recovery at the subacute stage after stroke.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2025

Same author

The role of muscle synergies and task constraints on upper limb motor impairment after stroke.

Experimental brain research·2025

Same author

Tired and out of control? Effects of total and partial sleep deprivation on response inhibition under threat and no-threat conditions.

Sleep·2024

Search research articles

Related Experiment Video

Updated: Feb 18, 2026

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Published on: June 6, 2025

Revisiting interhemispheric imbalance in chronic stroke: A tDCS study.

Alana B McCambridge¹, James W Stinear², Winston D Byblow²

¹Department of Exercise Sciences, University of Auckland, New Zealand; Centre for Brain Research, University of Auckland, New Zealand; Graduate School of Health, University of Technology Sydney, Australia.

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology

|November 18, 2017

Summary

Anodal transcranial direct current stimulation (a-tDCS) increased brain excitability in stroke survivors with moderate-severe motor impairment. This suggests a-tDCS may offer a novel therapeutic approach for improving motor function after stroke.

Keywords:

Contralesional Interhemispheric competition Magnetic resonance imaging Magnetic resonance spectroscopy Stroke TMS Transcranial direct current stimulation Transcranial magnetic stimulation tDCS

More Related Videos

The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism

The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism

Published on: November 19, 2014

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

Related Experiment Videos

Last Updated: Feb 18, 2026

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Published on: June 6, 2025

The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism

The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism

Published on: November 19, 2014

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

Area of Science:

Neuroscience
Rehabilitation Medicine
Neurology

Background:

Chronic stroke patients with moderate-to-severe motor impairment often exhibit altered motor control strategies.
There is a potential reliance on contralesional motor areas for controlling the paretic limb in these patients.

Purpose of the Study:

To investigate if enhancing contralesional motor cortex excitability using anodal transcranial direct current stimulation (a-tDCS) can improve motor performance.
To assess the effects of a-tDCS on motor function in chronic stroke patients with moderate-to-severe impairment.

Main Methods:

Ten chronic stroke patients with moderate-to-severe motor impairment participated.
Participants received a-tDCS, cathodal tDCS (c-tDCS), and sham stimulation targeting the contralesional motor cortex (M1).
Motor performance, corticospinal excitability, corticospinal tract integrity, and basal GABA concentration were assessed.

Main Results:

Anodal tDCS significantly increased contralesional corticomotor excitability.
Cathodal tDCS did not significantly alter corticomotor excitability.
The impact of tDCS on motor performance was negatively correlated with ipsilesional GABA concentration following c-tDCS.

Conclusions:

Anodal tDCS effectively modulates contralesional motor cortex excitability in chronic stroke patients.
Further research into non-invasive brain stimulation protocols, like a-tDCS, is needed to facilitate contralesional M1 function.
The findings suggest the inter-hemispheric imbalance model may require re-evaluation for patients with more severe stroke impairments.