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Autosomal dominant polycystic kidney disease combined with hypertrophic cardiomyopathy: A case report

Yingjing Shen1, Chenggang Xu

  • 1Department of Nephrology, Third Affiliated Hospital of Second Military Medical University, Shanghai, China.

Medicine
|November 18, 2017
PubMed

Insights

This case report details a patient with autosomal dominant polycystic kidney disease (ADPKD) and hypertrophic cardiomyopathy (HCM) who experienced acute kidney injury. Treatment led to remission of kidney injury and preserved cardiac function.

Area of Science:

  • Nephrology
  • Cardiology
  • Genetics

Background:

  • Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder.
  • Hypertrophic cardiomyopathy (HCM) is a cardiac condition often linked to genetic factors.
  • The co-occurrence of ADPKD and HCM is rare and presents complex clinical challenges.

Observation:

  • A 48-year-old male presented with symptoms of fluid overload and acute kidney injury (AKI).
  • Diagnostic imaging confirmed ADPKD with enlarged kidneys and HCM with significant left ventricular hypertrophy.
  • Initial treatments for ADPKD and associated complications were ineffective.

Findings:

  • The patient developed AKI following acute respiratory distress syndrome, posing a cardiac risk.
  • Treatment with prednisone and continuous renal replacement therapy resulted in improved renal function.
  • This represents the first reported case of ADPKD coexisting with HCM, achieving complete AKI remission and cardiac function preservation.

Implications:

  • Early detection and management are crucial for ADPKD patients experiencing rapid renal function decline.
  • This case highlights the importance of considering cardiac complications in ADPKD patients.
  • Further research into the interplay between ADPKD and HCM is warranted.
Abstract

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