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Sequential Firing Codes for Time in Rodent Medial Prefrontal Cortex.

Zoran Tiganj1, Min Whan Jung2,3, Jieun Kim2

  • 1Department of Psychological and Brain Sciences, Center for Memory and Brain, Boston University, Boston, MA USA.

Cerebral Cortex (New York, N.Y. : 1991)
|November 18, 2017
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Summary

Researchers found sequential time cells in the medial prefrontal cortex (mPFC) of rodents. These mPFC time cells exhibit properties similar to those in the hippocampus, suggesting a common neural mechanism for time representation.

Keywords:
mPFCsequential codingtime cells

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Background:

  • Time cells, neurons firing sequentially during delay intervals, are known in the hippocampus and striatum.
  • The presence and properties of time cells in the medial prefrontal cortex (mPFC) remain largely unexplored.

Purpose of the Study:

  • To investigate the existence of time cells in the rodent mPFC.
  • To compare the temporal properties of mPFC time cells with those found in other brain regions.

Main Methods:

  • Recorded neuronal activity in the rodent mPFC during a temporal discrimination task.
  • Analyzed firing patterns of individual neurons across multiple trials.
  • Correlated neuronal firing with elapsed time, animal position, and velocity.

Main Results:

  • Identified a subpopulation of mPFC neurons exhibiting sequential, time-locked firing patterns during a delay interval.
  • Demonstrated that the temporal accuracy of these mPFC time cells, measured by firing field width and cell population activity, decreased over time.
  • Found that elapsed time, rather than position or velocity, was the primary determinant of mPFC time cell firing dynamics.

Conclusions:

  • The medial prefrontal cortex contains sequentially activated time cells.
  • The properties of mPFC time cells are consistent with those observed in the hippocampus and striatum.
  • These findings suggest that time cells represent a common neural motif for temporal processing across multiple brain regions.