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Updated: Feb 18, 2026

Transdermal Measurement of Glomerular Filtration Rate in Mice
Published on: October 21, 2018
[Measurement and estimation of glomerular filtration rate]
Emmanuelle Vidal-Petiot1, Martin Flamant2
1Service de physiologie, explorations fonctionnelles, hôpital Bichat, 46, rue HenriHuchard, 75877 Paris cedex, France.
Abstract:
Glomerular filtration rate is the best quantitative marker of renal function. It allows diagnosis and classification of severe chronic kidney disease into five stages. Theoretically, the measurement of glomerular filtration rate is based on the calculation of urinary clearance of exogenous substances such as chromium 51-labeled inulin or ethylenediaminetetraacetic acid ([51Cr]-EDTA). In practice, glomerular filtration rate is most often estimated from equations derived from plasma creatinine. This article reviews the range of methods used to measure or approximate glomerular filtration rate and attempts to describe recent developments in this area, including those related to plasma creatinine assay methods, creatinine and cystatin C concentration-derived estimations. Measurement of glomerular filtration rate by the clearance of exogenous tracers is also discussed.
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