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Exploring gold nanoparticles interaction with mucins: A spectroscopic-based study.

Nadia Barbero1, Martina Coletti2, Federico Catalano1

  • 1Department of Chemistry and NIS Interdepartmental Centre, University of Torino, via Pietro Giuria 7, 10125 Torino, Italy.

International Journal of Pharmaceutics
|November 18, 2017
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Summary

Gold nanoparticles (GNPs) interact with porcine stomach mucin (PGM) and bovine submaxillary gland mucin (BSM). This mucin-nanoparticle complex formation is significant for biomedical applications in diseases involving mucus anomalies.

Keywords:
Circular dichroismFluorescence spectroscopyGold nanoparticlesMucinUV–vis spectroscopy

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Biochemistry

Background:

  • Mucins are crucial glycoproteins involved in mucus formation and rheology.
  • Anomalies in mucin composition and quantity are implicated in various diseases.
  • Gold nanoparticles (GNPs) offer potential for biomedical applications.

Purpose of the Study:

  • To investigate the interaction and affinity between gold nanoparticles (GNPs) and two types of mucins: porcine stomach mucin (PGM) and bovine submaxillary gland mucin (BSM).
  • To explore how GNP size and surface functionalization influence these interactions.
  • To assess the potential of GNP-mucin complexes for biomedical applications.

Main Methods:

  • UV-vis spectroscopy
  • Fluorescence spectroscopy and fluorescence lifetime measurements
  • Circular dichroism spectroscopy
  • Transmission electron microscopy (TEM)

Main Results:

  • Complex formation was observed between GNPs and both PGM and BSM across various sizes and functionalizations.
  • The study confirmed the affinity of GNPs to mucin proteins under physiological conditions.
  • Spectroscopic and microscopic analyses provided detailed insights into the interaction mechanisms.

Conclusions:

  • Gold nanoparticles (GNPs) form stable complexes with porcine stomach mucin (PGM) and bovine submaxillary gland mucin (BSM).
  • These findings highlight the potential of using GNPs in biomedical contexts, particularly for diseases characterized by mucin anomalies.
  • Understanding GNP-mucin interactions is vital for developing targeted therapies and diagnostic tools for mucus-related disorders.